"The Transposon Theory of Aging and SARS-CoV-2

Even mild COVID infection accelerates aging by activating Transposable Elements"

https://wmcresearch.substack.com/p/the-transposon-theory-of-aging-and

Worth reading to help one get a grasp on just how diabolical the bioweapons know as SARS-COV2 and the COVID-19 mRNA gene therapies really are...

It is hard for moral Humans to understand the depth of pure EVIL behind this war on us all. Those complicit in the on-going attack on Humankind deserve the worst punishments that can be bestowed upon them. 

This entire affair was not only unnecessary, but avoidable had the medical profession stood its ground in defense of our patients. It failed horribly..

https://salemyoussefmohamed.blogspot.com/2024/04/prognostic-value-of-andc-score-and-crp.html

Shimaa Abdelmoneem a, Rasha E. Omar b, Nabila Hassan Ahmed c, Sara Refaee Abdo Mohamed c, Mohammad Walaa d, Ahmad Abbas d, Eman M. Abdel-Sattar e, Abdullah Mohammad Abdel-hameed f, Lobna A. El-Korashi g, Salem Youssef Mohamed h, Tse-Wei Chen i, Reem M. Aljowaie j, Saeedah Musaed Almutairi j, Ahmed Embaby a

aClinical Hematology Unit, Internal Medicine Department, Faculty of Medicine, Zagazig University, Zagazig, EgyptbInternal Medicine Department, Faculty of Medicine, Zagazig University, Zagazig, EgyptcTropical Medicine Department, Faculty of Medicine, Zagazig University, Zagazig, EgyptdChest Department, Faculty of Medicine, Zagazig University, Zagazig, EgypteFamily Medicine Department, Faculty of Medicine, Zagazig University, Zagazig, EgyptfClinical Pathology Department, Faculty of Medicine, Zagazig University, Zagazig, EgyptgMedical Microbiology and Immunology Department, Faculty of Medicine, Zagazig University, Zagazig, EgypthGastroenterology and Hepatology Unit, Internal Medicine Department, Faculty of Medicine, Zagazig University, EgyptiDepartment of Materials, Imperial College London, London, SW7 2AZ, United KingdomjDepartment of Botany and Microbiology, College of Science, King Saud University, Saudi Arabia

SARS-CoV-2 has been a causative agent of severe acute respiratory syndrome since 2019. Early diagnosis of severe cases is crucial to decrease a patient's hospital stay and death risk. Severity and prognosis

This retrospective study included COVID-19 patients who underwent chest computed tomography scan and a battery of laboratory tests, including measurements of leukocytes, neutrophils, lymphocytes, lactic dehydrogenase, creatinine level, ferritin, D-dimer, albumin, and C-reactive protein. In addition, the CRP to lymphocyte ratio (CLR), CRP to albumin ratio (CAR), CRP to platelet ratio (CPR), and the ANDC score. Patients' clinical outcomes were recorded, including length of hospital stays (LOS) and mortality.

Out of 98 patients, 51 patients had passed away. There was a statistically significant difference between survivors and non-survivors regarding age, TLC, ANC, NLR, D-Dimer, and albumin. Moreover, a highly statistically significant difference regarding CRP levels, CAR, CPR, CLR, and ANDC was noted. Serum CRP level > 123 ng/ml, CAR > 36.77, CPR level > 462, and CLR > 84 had sensitivity (64.71 %, 66.6 %, 72.5 %, and 76.4 %, respectively) and specificity (85.1 %, 78.7 %, 72.3 %, and 72.3 % respectively) in mortality prediction. Meanwhile, the ANDC score was the most sensitive indicator (88.2 %) for mortality outcomes. Multivariable regression analysis revealed that aging, CPR, and ANDC level were independently associated with mortality with H.R. [1.025 (1.002–1.050); 2.338 (1.189–4.599) and 2.896 (1.191–7.044)]

The value of the ANDC score and CRP-derived inflammatory indicators correlate with the likelihood of mortality, so the efficacy of these metrics might assist in urgent early dialogues about treatment escalation.

TUESDAY, April 16, 2024 (HealthDay News) -- The Biden Administration announced Tuesday that it will work with 50 nations worldwide to try to prevent global pandemics such as COVID-19, which brought the world to a standstill four years ago.

"Today, I am proud to announce that my Administration is releasing a new Global Health Security Strategy -- outlining actions the United States will take over the next five years to prevent, detect and effectively respond to biological threats, wherever they emerge," President Joe Biden said in a statement posted by the White House.

As part of the initiative, the United States will offer support and expertise to nations, largely in Africa and Asia, aimed at boosting the preparedness, detection and response to emerging outbreaks.

The U.S. State Department, the U.S. Centers for Disease Control and Prevention, the U.S. Department of Health and Human Services and the U.S. Agency for International Development (USAID) will each take part.

The new effort expands what the administration calls its "global health security partnerships" from 19 countries to 50, the White House said in a fact sheet on the new strategy.

"In a health emergency, countries need to be able to quickly access financing to fortify their health systems, procure medical countermeasures and launch an effective response," the fact sheet said.

As the world's biggest investor in health security, the United States will collaborate with countries and key organizations "to identify and strengthen solutions to enhance access to financing for pandemic preparedness and response," the statement said.

CDC Director Dr. Mandy Cohen noted that her agency is at the ready.

"Global health security is national security, and CDC is proud to contribute its expertise, investments and rapid response to protect the health and safety of the American people and the world," Cohen said in an agency news release on the initiative. “CDC’s decades of global health investments, training and scientific diplomacy strengthen global capacity in labs, data, emergency response and the public health workforce."

As reported by the Associated Press, the White House initiative may help close a major gap in international pandemic preparedness. Attempts to have all 194 member states of the World Health Organization sign on to a pandemic treaty have stalled.

More information

Find out more about global pandemic preparedness at the U.S. Centers for Disease Control and Prevention.

SOURCES: White House, news release, April 16, 2024; Associated Press

Copyright © 2020 HealthDay. All rights reserved.

COVID-19 drug discovery and treatment options https://t.co/qWOIIiIeP3 In this Review, Kwok-Yung Yuen & co explore major drug discovery approaches, preclinical antiviral evaluation models, virus-targeting and host-targeting therapeutic strategies, and current key treatments. https://t.co/Ss2NxJv1UpApril 16,2024

MONDAY, April 15, 2024 (HealthDay News) -- Pediatric mental health (MH) emergency department visits were lower during the late pandemic period than prepandemic, according to a study published online April 2 in Academic Emergency Medicine.

In a retrospective study, Jennifer A. Hoffmann, M.D., from the Ann & Robert H. Lurie Children's Hospital of Chicago, and colleagues examined how pediatric MH emergency department visits during the COVID-19 pandemic differed from expected prepandemic trends. Children aged 5 to <18 years at nine U.S. hospitals were included from 2017 to 2022. Visit length was described by time period: prepandemic, early pandemic, midpandemic, and late pandemic (January 2017 to February 2020; March 2020 to December 2020; 2021; and 2022, respectively). Rate ratios (RRs) of observed to expected visits per 30 days during each pandemic time period were calculated.

A total of 175,979 pediatric MH emergency department visits were identified. For 7.3, 8.4, 15.0, and 19.2 percent of prepandemic, early pandemic, midpandemic, and late pandemic visits, respectively, visit length exceeded 12 hours. The researchers found that compared with expected rates, observed visits per 30 days decreased during the early pandemic (RR, 0.80; 95 percent confidence interval, 0.78 to 0.84), were similar during the midpandemic (RR, 1.01; 95 percent confidence interval, 0.96 to 1.07), then decreased during the late pandemic (RR, 0.92; 95 percent confidence interval, 0.86 to 0.98). Visits were higher than expected for females and for bipolar disorders, schizophrenia spectrum disorders, and substance-related and addictive disorders.

"Our results have relevance to policy considerations and the development of tailored interventions to improve youth mental health," the authors write.

Abstract/Full Text

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