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Social Needs Linked to Lower HRQOL for Black Cancer Survivors

MONDAY, Nov. 23, 2020 (HealthDay News) -- Social needs are associated with lower health-related quality of life (HRQOL) among African American cancer survivors, according to a study published online Nov. 23 in Cancer.

Theresa A. Hastert, Ph.D., from the Wayne State University School of Medicine in Detroit, and colleagues estimated the correlations between social needs and HRQOL among 1,754 survivors of breast, colorectal, lung, and prostate cancer from the Detroit Research on Cancer Survivors cohort. The validated Functional Assessment of Cancer Therapy-General (FACT-G) was used to measure HRQOL.

The researchers found that 36.3 percent of the survivors reported social needs, with 17.1 percent of survivors reporting two or more. There was variation in the prevalence of social needs, from 8.9 to 14.8 percent for utility shutoffs and food insecurity, respectively. The validated FACT-G score differences associated with social needs were −12.2, −11.3, −10.1, −9.8, −8.6, and −6.7 for not getting care due to lack of transportation, housing instability, food insecurity, feeling unsafe in the neighborhood, utility shutoffs, and not getting care because of cost, respectively.

"My hope is that these findings raise awareness among cancer care providers and cancer researchers that many patients face substantial social and financial difficulties and that these have real impacts on patients' health-related quality of life on top of cancer and cancer treatment," Hastert said in a statement.

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WHO: Remdesivir Not Advised for Hospitalized COVID-19 Patients

MONDAY, Nov. 23, 2020 (HealthDay News) -- The use of remdesivir currently is not recommended for hospitalized COVID-19 patients because of the lack of evidence for improvement in mortality, need for mechanical ventilation, and other patient-important outcomes, according to a living guideline published online Nov. 20 in The BMJ.

Bram Rochwerg, M.D., from McMaster University in Hamilton, Ontario, Canada, and colleagues examined the role of drug interventions in the treatment of COVID-19 in a living guideline, focusing on remdesivir, following the Oct. 15, 2020, preprint publication of results from the World Health Organization SOLIDARITY trial. To develop and disseminate living guidance for COVID-19 drug treatments, the WHO partnered with the Magic Evidence Ecosystem Foundation for methodologic support.

The new recommendation was weak or conditional against the use of remdesivir in hospitalized COVID-19 patients. The researchers emphasized that the evidence indicated no important effect on mortality, need for mechanical ventilation, time to clinical improvement, or other patient-important outcomes. Because the evidence was low or very low certainty for all outcomes, it was interpreted as not proving that remdesivir is ineffective; rather, no evidence is currently available that remdesivir does improve patient-important outcomes. Low value was placed on small and uncertain benefits in the presence of the possibility of important harms.

"This represents some of the strongest evidence yet that remdesivir is unlikely to be the lifesaving drug for the masses that many have hoped for," U.S. journalist, Jeremy Hsu, writes in an accompanying feature article.

Living WHO Guideline

Feature Article

Post-covid ground glass opacities

Dear colleagues, there are some patients having newly developed diffuse ground glass opaicites worse than before. Their PCR results are negative. These patients have severe hypoxia. What is your approach, pulse steroid?

Thank you

Metabolic Syndrome and COVID-19

Enhanced ACE2 expression, pre-existing endothelial dysfunction and procoagulant state induced by adipocytokines dysregulation in metabolic syndrome may play a crucial role for the development of severe COVID-19

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